Obesity is a condition associated with the accumulation of excess fat in the body, energy\nimbalance, lipogenesis, etc., which increases adipose tissue mass through adipogenesis and poses\na health risk. Its prevalence has become an economic burden to the health care system and the\nworld at large. One of the alternatives to tackling obesity involves the use of bioactive compounds.\nWe critically examined the effects of Hibiscus sabdariffa extract (HSE) on various parameters associated\nwith the development of obesity such as; the effect of HSE on body weight, the effect of HSE on\nlipid accumulation, cholesterol metabolism and plasma parameters, the inhibitory effect of HSE\non pancreatic lipase, and the effect of HSE on adipocyte differentiation/adipogenesis. This review\nhas gathered reports on the various anti-obesity effects of H. sabdariffa bioactive compounds in cell\nand animal models, as well as in humans. Available toxicology information on the consumption\nof H. sabdariffa revealed that its toxicity is dose-dependent and may cause an adverse effect when\nadministered over a long period of time. Reports have shown that H. sabdariffa derived bioactive\ncompounds are potent in the treatment of obesity with an evident reduction in body weight, inhibition\nof lipid accumulation and suppression of adipogenesis through the...........
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